At The University of Minnesota Amplatz Children’s Hospital, administrators felt strongly that as a pediatric healthcare institution, they held a singular responsibility to create a healthy and nurturing atmosphere for children. Accordingly, their sustainability initiative was framed around children and their families. The Green Guide for Healthcare was used as a design tool to help maximize natural light in the interior spaces, emphasize specifications of non-toxic, locally sourced building materials, low VOC finishes, and provide natural places of respite for patients and staff. Materials with high recycled content such as Terrazzo, Kirei sorghum board and jute-backed resilient flooring helped shape an entirely PVC-free interior for optimal Indoor Air Quality. Customized IAQ tests were developed and implemented on-site with UMinn’s own International IAQ expert, Professor Andy Streifel. The siting of the new hospital also helped to substantially reduce the heat island effect for the campus, as it was built on an existing parking lot. The facility is very well-landscaped, including a roof garden, which also contributes to storm water management. The engineering systems, water conservation measures, daylighting/lighting design and materials were all evaluated and structured to reflect the institution’s commitment to ensuring that the facility meets the long term environmental, economic and social aspects of how the hospital interacts responsibly with its community.